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Gmeiner, William
One or more keywords matched the following items that are connected to Gmeiner, William
Item TypeName
Academic Article Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Academic Article Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts.
Academic Article Novel chemical strategies for thymidylate synthase inhibition.
Academic Article Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Academic Article A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Academic Article Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
Academic Article Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.
Academic Article Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP.
Academic Article Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
Concept Thymidylate Synthase
Academic Article Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity.
Grant IMPACT OF 5-FU ON THE STRUCTURE OF THE U4-U6 COMPLEX
Grant DNA-DIRECTED EFFECTS OF FdUMP(N)
Grant Development of a CF10 Predictive Gene Signature in CRC Organoids.
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  • Thymidylate Synthase